MIC Tea Time: Exploring Redox Dynamics with Genetic Biosensors and Chemogenetic Tools
MIC-Node Preclinical Imaging (PI) presents:
Speaker: Emrah Eroğlu, Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Türkiye
April 17, 2024, 4 pm CET, via Webex
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Exploring Redox Dynamics with Genetic Biosensors and Chemogenetic Tools
Abstract: This presentation showcases recent advancements in employing innovative strategies for multiparametric imaging of cellular redox signaling events. Through the utilization of genetically encoded fluorescent protein-based biosensors targeting Calcium and reactive molecules such as ROS and RNS, the field of redox biology has experienced a transformative evolution. These tools offer unprecedented spatial and temporal resolution for visualizing biological processes, both in vitro and in vivo. Furthermore, the introduction of novel chemogenetic enzymes has broadened the array of genetically encodable tools, allowing precise manipulation of cellular and tissue-level redox tone. The integration of diverse genetic biosensors and chemogenetic devices has paved the way for groundbreaking investigations into ROS and RNS signaling pathways through multiparametric live-cell imaging, offering unparalleled precision. Yet, despite significant progress, there remains untapped potential in these approaches that redox biologists have yet to fully explore. This presentation will delve into recent breakthroughs and future prospects of these toolkits, emphasizing their capacity to bridge existing knowledge gaps in our comprehension of redox biology.
Emrah Eroğlu is affiliated to Istanbul Medipol University and the director of the Research Institute for Health Sciences and Technologies (SABITA) in Türkiye. His laboratory develops genetically encoded biosensors and chemogenetic tools to visualize ROS and RNS-dependent pathways in vascular cells. He has published several original and review papers on biosensors, chemogenetic tools, and the implication of ROS pathways in RNS signaling, primarily in the context of vascular cells. His team is also developing novel animal model systems of vascular dysfunction linked to neurodegenerative diseases.