MIC Festival 2024 Hands-On Session 3

MRI contrast agents: development, hands-on administration, measurements protocols and quantification

Come and join the MRI contrast agents hands-on session at the 6th MIC festival 2024.

Program:

l. Presentation of contrast agents (CAs) administration tools for in vivo examinations:

a) Injection-Phantom;

b) Remote bolus injection: injection pump & injection line.

II.  Show-casing of contrast-enhanced MRI measurements:

a) DCE measurements &

b) T1-mapping;

c) Quantification of population-based AIF (arterial-input-function)

III. Quantification of DCE parameter-maps: v_e - extravascular volume function, v_p - plasma function, k_trans - transfer constant

IV. Introduction on first experimental ¹⁹F-MRI probes with ultra-high ¹⁹F content, high aqueous solubility, and tunable structure/property relationships. Fluorinated versions related to the ones used in our application have been FDA-approved as stent coatings and as microbeads for cancer therapy.

Multimodal imaging is a further possibility with our platform, where multiple imaging-motifs (¹⁹F and ³¹P) can be incorporated into a single formulation, offering comprehensive diagnostic insights.

Team: Irena Pashkunova-Martic, Silvester Bartsch

Division of Structural and Molecular Preclinical Imaging,
Department of Biomedical Imaging and Image-guided Therapy

MIC-Node: DIP